Protocol for the Prevention of the Virus
by David Archibald
22 May 2021
The virus has not been all bad for health issues in Australia. The influenza infection rate and influenza deaths have collapsed in Australia, saving 800 lives per annum relative to the 2019 level of deaths. The preterm birth rate halved in a Queensland hospital during lockdown, similar to the 66% reduction in obstetric emergencies in an Indian hospital system, a 90% reduction in Denmark and a 73% reduction in Ireland. The reason is likely to be that the presence of the father at home during lockdown lowers the mother’s stress.
Otherwise, all is proceeding as it was foreseen. Singapore has had transmission between fully mRNA-vaccinated people. Vaccines for the Wuhan virus are now considered to need booster shots every six months to keep up with the mutation of the virus. The spike protein of the vaccines also does its own damage with a cumulative effect.
The University of Oklahoma has found that the India variant (B.1.617.2) is about six times more resistant than other variants to the antibodies generated by vaccines.
Until a better vaccine technology is developed, combinations of antivirals are likely to provide a higher level of protection. Quoting Professor McCullough:
Just like with acute HIV and hepatitis C and other viral illnesses, we have to use multiple drugs in combination. What we found is it takes about 4 to 6 drugs to be used in combination. We leveraged small clinical trials and observational studies with the signal of benefit and acceptable safety.
Modes of Action of Anti-Wuhan Virus Agents
- The main mode of action is inhibition of the importin (IMP) α/β receptor, which is responsible for transmitting viral proteins into the host cell nucleus.
- Ivermectin binds to both the spike of the coronavirus and to the ACE-2 receptor, interfering with the attachment of the spike to the human cell membrane.
- Ivermectin binds to RNA-dependent RNA polymerase (RdRp). RdRp is an enzyme that catalyzes the replication of RNA from an RNA template, thus inhibiting viral replication.
Ivermectin got its start as a treatment for parasitic worms. It is administered as a single oral yearly dose (e.g. 150 or 200 μg/kg) to treat onchocerciasis and strongyloidiasis. Lymphatic filariasis is similarly treated in endemic areas, with a once-yearly dose (300–400 μg/kg), or alternatively bi-yearly dosing (150–200 μg/kg).
Doses up to 2 mg/kg are well tolerated in patients with parasitic infections, with analysis of the first 11 years of mass global ivermectin (Mectizan) administration indicating a cumulative incidence of one serious adverse side effect case per million. Nobody has ever died from an ivermectin overdose.
That said, there are some moderate drug interactions with ivermectin, for example warfarin, listed here.
Vitamin D inhibits the ACE-2 receptor and reduces inflammation by decreasing interferon production.
Zinc inhibits RdRp elongation and reduces template binding in replication of the viral RNA.
Vitamin C directly inhibits viral replication enzymes and also works indirectly by increasing the production of antiviral proteins such as α/β interferons while down-regulating the production of pro-inflammatory cytokines TNF-α and IL-6. Also from that paper:
It is our experience, as well as others, that the sicker a person was, the more ascorbic acid they would tolerate orally without it causing diarrhea. A healthy person with a normal GI tract may tolerate 5 to 15 grams of ascorbic acid taken orally without diarrhea. A person with a mild cold may tolerate 30 to 60 grams; with a bad cold about 75 grams; with influenza close to 100 grams. With mononucleosis, viral pneumonia, etc. 150- 200 grams or more of ascorbic acid would be tolerated orally without diarrhea.
Quercetin is included in the protocol because it is a zinc ionophore, taking zinc ions from the intercellular fluid and pumping them into cells. It also has antiviral effects in its own right across a wide range of viruses. Hard numbers include an IC50 of 1 µg/ml against cytomegalovirus inoculated HeLa cells and an IC50 of 10.8 µg/ml against Dengue virus type 2 (DENV-2) replication in Vero cells. The latter was associated with a DENV-2 ribonucleic acid (RNA) reduction of 67%. This is attributed to querecetin’s ability to either block virus entry or inhibit viral replication enzymes such as viral polymerases. Quercetin is no slouch as an anticancer molecule either, with an IC50 against the prostate cancer cell line PC-3 of 6.7 µg/ml.
A study in 2008 found that quercetin is synergistic with vitamin C in protecting mice against exercise-driven influenza death.
There is no evidence that melatonin is viricidal, but rather it reduces the severity of these infections. Melatonin’s beneficial effects derive from its anti-inflammatory properties, free radical scavenging activity, and immunomodulatory functions. Melatonin production drops with age and it has been mostly older people who are the most-affected by the virus. Melatonin also protects mitochondria which are a target of the virus.
Formulated by Professor Paul Marik, Chief of Pulmonary and Critical Care Medicine, Eastern Virginia Medical School, the following is a prophylactic regime for keeping the virus at bay:
The potential efficacy of this combination can be calculated using data from this site as at 19th May, 2021:
Despite ivermectin’s wide therapeutic window, the recommended dosing regime has followed animal husbandry’s dosing on a milligram (mg) per kilo live weight basis. There are two forms of ivermectin available in Australia: Stromectol is the human version, while Cattlemax is for cattle. Formulations for other ruminants are much weaker. For example Cattlemax is 0.5% ivermectin whereas Ivomec for sheep is 0.08% ivermectin. Ivermectin formulations for dogs and other companion species should be avoided as other molecules for heart conditions etc. are included.
Each Stromectol contains 3 mg of ivermectin and has a retail price of $5.00 per tablet. Stromectol needs a prescription. Cattlemax can be ordered online.
Following is a table of the recommended dosing regime of ivermectin by weight:
|Body Weight||mg at||Number of||Cost||ml of||Cost|
Using Stromectol instead of Cattlemax as your source of ivermectin is about 70 times more expensive. Each Stromectol tablet is possibly only 1% ivermectin which means that someone taking eight tablets per dose is eating a lot of filler.
For someone weighing 120 kg and thus using 4.8 ml of Cattlemax per fortnightly dose point, a one litre bottle of Cattlemax will last eight years at an annual cost of about $15. Using Stromectol as the source of ivermectin would cost about $1,000 per annum.
David Archibald is the author of The Anticancer Garden in Australia.