Natural resistance to covid, and second generation vaccines that ignore the spike and recognize the proteins inside the covid virus

Natural resistance to covid, and second generation vaccines that ignore the spike and recognize the proteins inside the covid virus. By Pat Hagan.

There is mounting evidence that some people are naturally Covid-resistant. For reasons not fully understood, it’s thought that these people were already immune to the Covid virus, and they remain so even as it mutates. …

Experts hope that by studying these lucky individuals, they might unlock clues that will help them create a variant-proof vaccine that could keep Covid at bay for ever. …

When the UCL researchers examined the blood of seemingly Covid-proof healthcare workers that had been taken before the vaccine rollout, it confirmed they had no Covid antibodies — meaning it was unlikely they had ever been infected.

However, they discovered other immune system cells, called T cells, similar to those found in the immune systems of people who have recovered from Covid. Like antibodies, T cells are created by the immune system to fend off invaders. But while antibodies stop viral cells from entering the body, T cells attack and destroy them.

It is now known that Covid antibodies can begin to wane in a matter of months both after infection and after vaccination. However, T cells remain in the system for longer and will have snuffed out the virus before it had a chance to infect healthy cells or do any damage, experts suggested.

But why were they there in the first place?

One theory is that the protection came from regular exposure in the past. This could have been through their jobs dealing with sick patients or facing other, less destructive types of coronavirus — the type of disease that includes Covid, of which four strains cause common colds. …

The UCL team carried out further tests on hundreds more blood samples collected as far back as 2011, long before the pandemic struck, and discovered that about one in 20 also had antibodies that could destroy Covid.

Samples taken from children had the highest levels. Scientists said this was possibly because they were regularly exposed to cold-causing coronaviruses through mixing with large numbers of other youngsters at nursery and school, which could explain why, now, Covid rarely causes severe illness in this age group. …

Ignore the spike on the outside — recognize the proteins on the inside of the virus:

It appears the most likely explanation for a Covid-proof immune system is that, after it has been repeatedly exposed to another coronavirus, it is then able to detect and defeat any mutated relatives because it is recognising proteins found inside the virus rather than on its surface.

These vary little between coronaviruses. ‘Internal proteins don’t mutate at anything like the same rate as external ones,’ says Professor Andrew Easton, a virologist at Warwick University.

Vaccine-makers have been trying to come up with a jab that contains these stable internal proteins. One is being tested by Oxfordshire-based biotechnology firm Emergex.

It has developed a skin patch — rather than a jab — which sticks on the upper arm. Tiny micro-needles in the patch painlessly puncture the skin, allowing fragments of a range of viral proteins to seep through into the bloodstream and spark the release of anti-coronavirus T cells.

Trials, initially involving 26 volunteers, are due to begin in Switzerland with the earliest results by June.

‘These second-generation Covid vaccines will look at parts of the virus that are less prone to change than the spike protein,’ says Professor Lawrence Young, also a virologist at Warwick University. …


Scientists say the emergence of more vaccine-resistant variants is inevitable. …


Another plausible hypothesis is that natural Covid resistance — and a potential preventative treatment — lies in the genes.

At the University of Sao Paulo in Brazil, researchers have recruited 100 cohabiting couples where one was infected and symptomatic, while the other never tested positive and blood tests confirmed they carried no Covid-specific antibodies, meaning it’s unlikely they have ever caught the virus. The couples will have their DNA analysed to see if there are any key difference between them. …

Genetic resistance has been seen with other viruses. In the mid-1990s, doctors found that an American man, Stephen Crohn, despite having been exposed to numerous HIV-positive partners, had no signs of HIV infection. Researchers discovered he carried a genetic mutation that hampers HIV’s ability to infiltrate the body’s cells. …

Covid might just become less harmful, and omicron is a step in that direction:

Professor Julian Tang, a virologist at Leicester University, says: ‘I think the virus itself will get us out of this pandemic because it seems to be evolving into something much more benign.

‘The history of many viruses — including the Spanish flu of 1918 — is that they become more harmless in time. Current data suggests Omicron is significantly milder than earlier variants, but it is surprising that it has happened this quickly.

‘I would have expected this transition from dangerous and lethal virus to a benign one to take five to ten years, but it looks like it could happen much sooner than that.’ …

Crossover from flu vaccines:

Striking evidence from the US shows that people who had had a flu vaccine were 24 per cent less likely to catch Covid-19 — regardless of whether they’d had the Covid vaccine. And those who did contract Covid were less likely to need hospitalisation or ventilation.

The first generation vaccines are not the solution to covid. Vaccine mandates are immoral, ineffective, and cause real harm.