Original Antigenic Sin and the Folly of Our Universal Vaccination Campaign. By Eugyppius.
We have now had ten months of mass vaccination against SARS-CoV-2. Nearly 7 billion doses have been administered worldwide. This unprecedented campaign has not eradicated Corona; it has not even suppressed infections. Instead, case statistics have ballooned almost everywhere. While the vaccinated appear to enjoy some protection against severe outcomes, skyrocketing transmission means most countries have seen little benefit, on balance, from their universal vaccination campaigns. The most pressing question has become, simply: What is going on?
Original antigenic sin:
The Public Health England data provide powerful reasons to suspect that the vaccines may be compromising immunity to SARS-2 via Original Antigenic Sin.
This is not a crazy internet fantasy, but a well-observed limitation of human immunity. It is the primary reason that respiratory viruses like influenza return again and again. Despite multiple reinfections across the whole population, we are never quite immune to the flu, because its strategy is to exploit the way our immune systems learn.
The mechanisms of Original Antigenic Sin are not fully understood, but we have a rough idea of what might be happening. When a virus infects your body for the first time, your naive memory B cells imprint on specific virus proteins, or antigens, presented to them. These B cells then become either memory B cells or plasma cells. Forever after, they specialise in producing antibodies against those specific antigens.
When a slightly mutated form of the virus arrives, these memory B-cells begin pouring forth the antibodies
they learned to produce during the first infection. These antibodies bind to multiple epitopes on the virus particles, and in the process they give the slower-moving naive B-cells little chance to learn about any new, mutant virus features.
Original Antigenic Sin was most influentially described by Thomas Francis in 1960. He noted that, regardless of whatever influenza A strains were in circulation, subjects tended to have dominant antibody responses to the strains that were current in their early childhood …
An important consequence of this childhood conditioning, is that different age cohorts within the population have overlapping or layered immunity to different influenza strains. As older cohorts die, their immunity to older strains dies with them. These old strains, long suppressed, are then positioned to return, for very few human immune systems remember them any longer. Francis believed this was the mechanism underlying periodic cycles of pandemic influenza. …
Flu shots basically only work if you’ve never had flu before, which is why they are so ineffective:
The existence of Original Antigenic Sin has been confirmed by generations of research, and the literature is full of curious findings.
A major reason flu shots don’t work, for example, is that they are powerless to redirect adult immune systems against novel influenza strains. Most people who get flu shots are adults, with immune systems long since primed by childhood infection. …
The flu vaccines, in other words, work great if you’ve never had the flu before. Otherwise they don’t do anything. …
Earlier research [showed] substantial all-cause mortality reductions from flu shots. Later work, though, has shown that the mortality reduction of influenza vaccines is largely an illusion of selection effects. For a variety of reasons, those most likely to die of influenza are far less likely than healthier groups to be vaccinated. …
In chasing an empty fantasy of herd immunity, authorities are denying human populations everywhere the opportunity to develop the layered, population-wide resistance against successive SARS-2 strains that is the foundation of our immunity against other respiratory viruses.
Aside from the minority that have managed to recover from natural infection before the vaccinators got to them, most humans will have their crucial, primary immune response conditioned by the spike protein of SARS-2 in its vintage 2020 configuration.
It is a near certainty that this immunity will attenuate antibody responses to the spike protein of current and future variants, forever. … Insofar as the data also suggest that our vaccines will attenuate immunity to other virus proteins beyond spike, mass vaccination will lead to ever more volatile waves of infection — in exchange for limited and fading protection against severe outcomes.
The most dangerous thing to do, at this point, would be to vaccinate children. The virus is not a threat to them, and if they are infected by the new forms of SARS-2 that are sure to emerge every winter, we will begin to establish — through them and the as yet unvaccinated — the layered immunity that is the only way of coming to terms with SARS-2 in the longer term.
As long as the vaccinators are permitted to continue their radical and increasingly insane campaign, though, nothing will improve. Indeed, their policies threaten to bring about a semi-permanent pandemic state for generations to come.
And who would benefit from that? Drug companies obviously, but also big government and those wishing to erode democracy and institute rule by bureaucratic “experts” instead. Imagine having the whole of humanity hooked on receiving timely injections — like modern chickens needing vaccination against Marek’s disease or they die. Imagine the power.