Mass Vaccination Delays Herd Immunity and Risks Greater Damage, Unless a Sterilizing Vaccine Can Be Found

Mass Vaccination Delays Herd Immunity and Risks Greater Damage, Unless a Sterilizing Vaccine Can Be Found. By Geert Vanden Bossche, who earned his PhD degree in Virology from the University of Hohenheim, Germany. More about him:

He has worked for several vaccine companies (GSK Biologicals, Novartis Vaccines, Solvay Biologicals) to serve various roles in vaccine R&D as well as in late vaccine development.

He also joined the Bill & Melinda Gates Foundation’s Global Health Discovery team in Seattle (USA) as Senior Program Officer before working with the Global Alliance for Vaccines and Immunization (GAVI) in Geneva as Senior Ebola Program Manager. At GAVI he tracked efforts to develop an Ebola vaccine. He also represented GAVI in fora with other partners, including WHO, to review progress on the fight against Ebola and to build plans for global pandemic preparedness.

He then joined the German Center for Infection Research in Cologne as Head of the Vaccine Development Office.

So this guy is unimpeachably a real expert, not just your average midwit health bureaucrat.

He had some interesting things to say in a statement yesterday (which we have excerpted, and translated somewhat from its formal and stilted language). The summary:

Mass vaccination in the middle of a pandemic is prone to promoting selection and adaptation of immune escape variants that are featured by increasing infectiousness and resistance to [antibodies that are specific to covid’s distinctive spike], thereby diminishing protection in vaccinees and threatening the unvaccinated.

This already explains why the WHO’s mass vaccination program is not only unable to generate herd immunity but even leads to substantial erosion of the population’s immune protective capacity. … Every further increase in vaccine coverage rates will further contribute to forcing the virus into resistance to [spike-specific antibodies].

Increased viral infectivity, combined with evasion from antiviral immunity, will inevitably result in an additional toll taken on human health and human lives.

Immediate action needs, therefore, to be taken in order to dramatically reduce viral infectivity rates and to prevent selected immune escape variants from rapidly spreading through the entire population, whether vaccinated or not.

This first critical step can only be achieved by calling an immediate halt to the mass vaccination program and replacing it by widespread use of antiviral chemoprophylactics [such as ivermectin and HCQ] while dedicating massive public health resources to scaling early multidrug treaments of Covid-19 disease. …

Now for some details. Innate immunity, not spike-specific antibodies, is the key to long-term protection and building herd immunity — even though spike-specific antibodies bind to covid more readily:

Innate immunity critically contributes to protecting a population from Covid-19. This is why children and healthy people … are enjoying a significant degree of protection from Covid-19 disease. Natural, innate antibodies and natural killer cells can target non-mutable common structures in otherwise highly mutating viruses and hence, deal with all Sars-CoV-2 variants. However, as they merely serve a first line of immune defense and have relatively low affinity [for binding to the covid virus], they’re not armed well enough to deal with high concentrations of pathogens …

The modellers and vaccine makers are not taking this into account, which is why they are failing:

To my knowledge, none of the current mathematical models [take into account] the susceptibility of our innate immune defense to enhanced viral infectiousness. As this is a major prerequisite for understanding the selection and dominant propagation of increasingly infectious variants, … predictions from these modelling exercises have not become true. None of them have even come close to reality.

Failure to take into account the role of innate … multipathogen-specific [antibodies] and [natural killer] cells is the single most important explanation for why the mechanistics behind the increasing infectiousness of circulating viral variants and their rapidly advancing evasion from antiviral immunity have remained elusive.

Although multiple peer-reviewed publications have repeatedly highlighted the pivotal role of natural, multipathogen-specific antibodies in a myriad of natural immune defense mechanisms, the vast majority of vaccinologists, virologists and epidemiologists don’t seem to even be aware of the functional importance of these [antibodies].

Current vaccines increase spike-specific antibodies, but — by natural selection — are inevitably just leading to covid strains that evade them. Which is why the more generalist, innate immunity and multi-purpose antibodies are, in the long term, more important:

In parallel with universal vaccination, more infectious strains have rapidly expanded in prevalence. According to molecular epidemiologists, Sars-CoV-2 is now also rapidly evolving towards resistance to [spike-specific] Sars-CoV-2 [antibodies]. …

There can be no doubt that resistance to vaccinal [spike-specific antibodies] will be the endpoint of any mass vaccination program that uses modern vaccines during a pandemic of an acute self-limiting viral disease caused by a highly mutable virus. …

Contrary to live vaccines, vaccines produced by modern vaccine technologies fail to induce sterilizing immunity [that is, they do not kill the virus in you, but merely protect you from its worst consequences]. … As abundantly reported in the literature and social media, vaccinated subjects do not only spread Sars-CoV-2 variants but are now also increasingly developing symptomatic infections …

Mass vaccination is hazardous to the public in the long term:

It is critical to understand how mass vaccination is inevitably driving this pandemic of highly infectious antigenic variants into a direction that is very hazardous to public and global health. …

High vaccine coverage rates eventually turn populations [into] excellent breeding grounds for … vaccine-resistant variants. Even if the latter are not bred directly in the highly vaccinated population, they can readily use such a population as a convenient petri dish for their expansion in prevalence …

As the virus mutates to evade the spike-specific antibodies, vaccinated people will get sick and die more often. Meanwhile, the unvaccinated part of the population will get sick and die less often because it will contain fewer and fewer covid-susceptible people.

The presence of the spike-specific antibodies suppresses the innate immunity and the general-purpose antibodies. Oh dear.

The more young and healthy individuals are vaccinated, the larger the fraction of the population in which variant-nonspecific innate [antibodies] experience prolonged suppression by vaccinal [antibodies] and … the more likely naturally selected, more infectious variants will find a suitable breeding ground for their expansion, and the faster these more infectious variants will start to prevail. … As long as vaccine resistance does not occur, vaccinal [spike-specific antibodies] will bind to Sars-CoV-2 and hence, outcompete natural [antibodies] in vaccinees. …

Eventually the sickness and death rates in the vaccinated will exceed those of the unvaccinated:

It is reasonable to conclude that continued mass vaccination, together with the predominant circulation of more infectious variants (as facilitated by mass vaccination!), will inevitably lead to relatively higher morbidity and mortality rates in vaccinees than in the nonvaccinated. It also follows that the more the vulnerable, but unvaccinated, part of the population will adhere to rigorous infection prevention measures, the more the peak of morbidity and mortality will shift away from the unvaccinated to the vaccinated.

A better strategy (though perhaps not for financial fortunes of the pharmaceutical companies and their lobbyists):

  • Stop mass vaccination

  • Don’t proceed with updated vaccine shots

  • Roll out global antiviral chemoprophylaxis [e.g. ivermectin, HCQ] to diminish viral infectious pressure (this may need to also include relevant animal reservoirs!)

  • Until we have dramatically diminished the infectious viral pressure, global and stringent infection prevention measures are to be re-installed [i.e. border closures, quarantining, and lockdowns aimed at eradication]

  • Provide — at no cost — early multidrug treatment to all patients in need

  • Roll out campaigns to promote healthy diets and lifestyle

  • Implement all of the above to buy time for the development of a Universal Immunological Sterilizer that is capable of preventing or abrogating infection by any Sars-CoV-2 lineage [i.e. a real vaccine, that sterilizes us of covid instead of living with it and turning us into a Petri dish for mutation].

There can be no doubt that the toll taken on human lives, health and health care systems will be much higher if we allow NATURE to take care of our gigantic mistake.

Herd immunity, which is going to inevitably come from our innate immunity and general-purpose antibodies, is being delayed by spike-specific vaccines:

And even though [herd immunity] will finally be established, it may be much more fragile and heterogeneous for many years to come than the one that would have been established after a natural pandemic. This is because the [herd immunity] that puts an end to a pandemic of highly infectious Sars-CoV-2 variants will initially only rely on innate population-level immunity. …

[Herd immunity] could easily take half of a decade, especially in countries which have been combining heavy mass vaccination programs with stringent infection prevention measures.

Conclusions: Current vaccines are just making it worse…

There is no way the Sars-CoV-2 pandemic could be controlled by the current, imperfect C-19 vaccines.

Using imperfect vaccines to control a pandemic (of a highly mutable virus causing acute, self-limiting viral infection) will only increase the toll Nature will take on human health and lives in return for regranting a license to rebuild [herd immunity]. …

Nature will first reset the population’s immune status to that of a Sars-CoV-2 naïve population, i.e., similar to what it was at the outset of this pandemic. The difference being, however, that the immunologically Sars-CoV-2 naïve population will now have to deal with viral variants that have a much higher level of infectiousness than the original Wuhan strain. This represents a formidable challenge to our innate immune system …

Artificial (human) immune intervention in a Coronavirus (CoV) pandemic could rapidly and durably yield immune protection of vulnerable individuals if and only if sterilizing immunity is induced. This means that the immune response induced is targeted at eliminating virus-infected cells. …

None of the current C-19 vaccines induces sterilizing immunity. They must not be used during a pandemic for they will merely drive immune escape and erode both innate immunity (i.e., by breeding more infectious variants that exert enhanced infectious pressure, and thereby render younger age groups more susceptible to the disease) and acquired immunity (i.e., by driving viral resistance to [spike-specific antibodies]).

See also here and here.