The Anti-Aging Pill is Here

The Anti-Aging Pill is Here, by Karen Weintraub.

The startup is being founded by Leonard Guarente, an MIT biologist … who’s convinced that the process of aging can be slowed by tweaking the body’s metabolism.

[T]here’s no guarantee that Elysium’s first product, a blue pill called Basis that is going on sale this week [over the counter], will actually keep you young.

The problem, Guarente says, is that it’s nearly impossible to prove, in any reasonable time frame, that drugs that extend the lifespan of animals can do the same in people; such an experiment could take decades. That’s why Guarente says he decided to take the unconventional route of packaging cutting-edge lab research as so-called nutraceuticals, which don’t require clinical trials or approval by the FDA.

Scientists have shown they can reliably extend the life of laboratory mice by feeding them less, a process known as “caloric restriction.” That process seems to be mediated by biological molecules called sirtuins. NAD is important because it’s a chemical that sirtuins need to do their work and is also involved in other aspects of a cell’s metabolism. In worms, mice, and people, NAD levels fall with age, says Guarente, so the idea is to increase levels of the molecule.
hat-tip Matthew